- Title
- The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention
- Creator
- Brzozowski, Joshua S.; Skelding, Kathryn A.
- Relation
- Pharmaceuticals Vol. 12, Issue 1, no. 8
- Publisher Link
- http://dx.doi.org/10.3390/ph12010008
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2019
- Description
- The importance of Ca2+ signalling in key events of cancer cell function and tumour progression, such as proliferation, migration, invasion and survival, has recently begun to be appreciated. Many cellular Ca2+-stimulated signalling cascades utilise the intermediate, calmodulin (CaM). The Ca2+/CaM complex binds and activates a variety of enzymes, including members of the multifunctional Ca2+/calmodulin-stimulated protein kinase (CaMK) family. These enzymes control a broad range of cancer-related functions in a multitude of tumour types. Herein, we explore the cancer-related functions of these kinases and discuss their potential as targets for therapeutic intervention.
- Subject
- CaMKK; CaMKI; CaMKII; CaMKIV; anti-cancer drugs; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1454517
- Identifier
- uon:44961
- Identifier
- ISSN:1424-8247
- Rights
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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